DTL (gene)

DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	OMIM: 610617; MGI: 1924093; HomoloGene: 32313; GeneCards: DTL; OMA:DTL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	212,107,400 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,307,656 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; trabecular bone; ; embryo; ; testicle; ; ventricular zone; ; bone marrow; ; ganglionic eminence; ; gonad; ; bone marrow cells; ; sperm;
	Top expressed in
	mandibular prominence; ; maxillary prominence; ; zygote; ; secondary oocyte; ; ureter; ; lumbar spinal ganglion; ; primitive streak; ; primary oocyte; ; hand; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding;
Cellular component	centrosome; nuclear membrane; membrane; chromosome; microtubule organizing center; nucleolus; Cul4A-RING E3 ubiquitin ligase complex; Cul4B-RING E3 ubiquitin ligase complex; cytoskeleton; nucleus; nucleoplasm; cytoplasm; cytosol; Cul4-RING E3 ubiquitin ligase complex;
Biological process	ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein monoubiquitination; regulation of cell cycle; DNA replication; protein ubiquitination; response to UV; translesion synthesis; post-translational protein modification; cellular response to DNA damage stimulus; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein catabolic process; mitotic G2 DNA damage checkpoint signaling; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	51514
	76843
	ENSG00000143476
	ENSMUSG00000037474
	Q9NZJ0
	Q3TLR7
	NM_001286229; NM_001286230; NM_016448
	NM_029766; NM_001305233
	NP_001273158; NP_001273159; NP_057532
	NP_001292162; NP_084042
	Wikidata
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