DUSP2

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesDUSP2, PAC-1, PAC1, dual specificity phosphatase 2

External IDsOMIM: 603068; MGI: 101911; HomoloGene: 3255; GeneCards: DUSP2; OMA:DUSP2 - orthologs

Chr.Chromosome 2 (human)^[1]

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DUSP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M3G
Identifiers
Aliases	DUSP2, PAC-1, PAC1, dual specificity phosphatase 2
External IDs	OMIM: 603068; MGI: 101911; HomoloGene: 3255; GeneCards: DUSP2; OMA:DUSP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 96,143,169 bp[1] End 96,145,440 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 127,178,079 bp[2] End 127,180,296 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula granulocyte lymph node mucosa of urinary bladder monocyte spleen testicle gallbladder bone marrow cell appendix Top expressed in mesenteric lymph nodes thymus spleen trachea blood granulocyte embryo lip tibiofemoral joint bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity mitogen-activated protein kinase binding Cellular component nucleus nuclear membrane cytoplasm Biological process protein dephosphorylation endoderm formation dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1844 13537 Ensembl ENSG00000158050 ENSMUSG00000027368 UniProt Q05923 Q05922 RefSeq (mRNA) NM_004418 NM_010090 RefSeq (protein) NP_004409 NP_034220 Location (UCSC) Chr 2: 96.14 – 96.15 Mb Chr 2: 127.18 – 127.18 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.^[8]