Born in Treviglio, Lombardy, Casiraghi started his career at a small Lombard team Tritium. He played for its reserve in 2010–11 season.[2] In March 2011 Casiraghi also scored in his league debut for the first team, against Sacilese. Casiraghi was a regular member of the first team in 2011–12 and 2012–13 Lega Pro Prima Divisione seasons. On 1 August 2013 Casiraghi was signed by Lecce in a 3-year contract.[3] On 17 August 2013 he appeared as an unused bench against Parma F.C. in 2013–14 Coppa Italia.[4] He left on loan to Pro Patria in the same transfer window.
On 30 June 2014 Casiraghi was signed by Serie A club Parma F.C. in a 4-year contract, with Abdou Doumbia moved to opposite direction.[5] Both players were valued for €1 million.[6]
On 16 July 2014 Casiraghi left for Gubbio along with Tommaso Domini, Alessandro Luparini, Michele Bentoglio and Pietro Manganelli in temporary deals.[7] On 25 June 2015 Casiraghi became a free agent, after the bankruptcy of Parma.
In July 2015 he was signed by Lega Pro club Ancona.[8] On 12 September 2016 he was signed by Gubbio.[9]
On 4 July 2019, he signed with Südtirol for two years with an option for a third.[10]
On 5 February 2022 against Renate, at the "Città di Meda" Stadium, Daniele Casiraghi achieves 100 caps with Südtirol.
Casiraghi received a call-up from Lega Pro representative team in November 2011 against Belgium U23 in 2011–13 International Challenge Trophy.[11][12] Casiraghi then received his first call-up from Italy U19 team in December 2011 against the Lega Pro representatives,[13] however he did not play. Casiraghi played twice in friendlies in February and March 2012 for U19 team. In April 2012 he represented Lega Pro to win a youth tournament in Dubai, winning Al-Shabab in the final.[14] In June 2012 he played for Lega Pro winning San Marino 8–0.[15]
In 2012–13 season he received call-up from Luigi Di Biagio for Italy national under-20 football team.