After finishing her PhD, Dutton joined the staff of Dalkey Archive Press, first as managing editor and then as production manager and book designer. She designed covers for such books as Stories and Essays of Mina Loy, Terra Nostra by Carlos Fuentes, The Log of the SS the Mrs Unguentine by Stanley Crawford, Suicide by Eduoard Leve, The Engineer of Human Souls by Josef Skvoreky, Perfect Lives by Robert Ashley, Ryder by Djuna Barnes, and more than 100 others, and was interviewed for her designs by Elle magazine.[8]
In 2010, Dutton founded the indie press Dorothy, a publishing project. The website states that Dorothy, a publishing project is dedicated "to works of fiction, or near fiction, or about fiction, mostly by women."[9] To date, the press has published books by Renee Gladman, Barbara Comyns, Manuela Draeger (translated from the French by Brian Evenson), Suzanne Scanlon, Azareen Van der Vliet Oloomi, Amina Cain, Joanna Ruocco, Nell Zink, Joanna Walsh, Marianne Fritz (translated from the German by Adrian Nathan West), Jen George, Nathalie Léger (translated from the French by Natasha Leher and Cécil Menon). Though it publishes only two books per year, the press has garnered wide praise and reviews of its books in such publications as the Los Angeles Times, Vice, The New York Times, and Harper's. Dutton has been interviewed about the press in magazines including the Paris Review Daily, Kirkus Reviews, BOMB, and for articles in Poets & Writers and Publishers Weekly. In a 2014 article in the Chicago Tribune, critic Laura Pearson wrote: "Truthfully, we'd check out anything from Dorothy, a publishing project, so keen is editor Danielle Dutton's eye for weird, wonderful manuscripts — most of which happen to be by women. Plus, the St. Louis-based press only puts out two books a year, so it's very doable."[10]