Danitracen

Danitracen
Identifiers
	IUPAC name 4-(6H-benzo[c][1]benzothiepin-11-ylidene)-1-methylpiperidine;
CAS Number	1447-70-7;
PubChem CID	35758;
ChemSpider	32893;
UNII	SD507F5T2W;
ChEMBL	ChEMBL440557;
CompTox Dashboard (EPA)	DTXSID70185156 ;
Chemical and physical data
Formula	C20H21NO
Molar mass	291.394 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCC(=C2C3=CC=CC=C3C(C4=CC=CC=C42)O)CC1;
	InChI InChI=1S/C20H21NO/c1-21-12-10-14(11-13-21)19-15-6-2-4-8-17(15)20(22)18-9-5-3-7-16(18)19/h2-9,20,22H,10-13H2,1H3; Key:HLBRHTFSMMEHPK-UHFFFAOYSA-N;

Danitracen (WA 335) is an antidepressant compound developed in the 1970s. Danitracen acts by blocking central and peripheral 5-HT receptors: it potentiates testosterone-induced sexual behavior in rats and abolishes the 5-hydroxytryptophan (5-HTP) induced hypermotility in mice. In amphetamine-treated rats, administration of danitracen lowered whole brain serotonin and norepinephrine levels. Danitracen was investigated in clinical trials in depressed patients. At 3 mg/day, danitracen was equipotent to 150 mg/day amitriptyline.^[1]^[2]^[3]^[4]^[5]^[6]

CAS Number

1447-70-7

PubChem CID

35758

ChemSpider

32893

UNII

SD507F5T2W

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Danitracen

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Identifiers

IUPAC name 4-(6H-benzo[c][1]benzothiepin-11-ylidene)-1-methylpiperidine
CAS Number	1447-70-7
PubChem CID	35758
ChemSpider	32893
UNII	SD507F5T2W
ChEMBL	ChEMBL440557
CompTox Dashboard (EPA)	DTXSID70185156
Chemical and physical data
Formula	C₂₀H₂₁NO
Molar mass	291.394 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1CCC(=C2C3=CC=CC=C3C(C4=CC=CC=C42)O)CC1
InChI InChI=1S/C20H21NO/c1-21-12-10-14(11-13-21)19-15-6-2-4-8-17(15)20(22)18-9-5-3-7-16(18)19/h2-9,20,22H,10-13H2,1H3 Key:HLBRHTFSMMEHPK-UHFFFAOYSA-N