DcuC family
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| C4-dicarboxylate anaerobic carrier | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DcuC | ||||||||
| Pfam | PF03606 | ||||||||
| Pfam clan | CL0182 | ||||||||
| InterPro | IPR018385 | ||||||||
| TCDB | 9.B.50 | ||||||||
| |||||||||
The C4-dicarboxylate uptake C family or DcuC family (TC# 2.A.61) is a family of transmembrane ion transporters found in bacteria.[1] A representative list of proteins belonging to the DcuC family can be found in the Transporter Classification Database.
An anaerobic C4-dicarboxylate transporter (DcuC) of E. coli (TC# 2.A.61.1.1) has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake.[2][3] DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates).[4][5]
The reactions probably catalyzed by the E. coli DcuC protein are:
- C4-dicarboxylate (out) + nH+ (out) → C4-dicarboxylate (in) + nH+ (in)
- C4-dicarboxylate1 (out) + C4-dicarboxylate2 (in) ⇌ C4-dicarboxylate1 (in) + C4-dicarboxylate2 (out).
