De Kimpe aziridine synthesis
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| De Kimpe aziridine synthesis | |
|---|---|
| Named after | Norbert De Kimpe |
| Reaction type | Ring forming reaction |
| Identifiers | |
| Organic Chemistry Portal | de-kimpe-aziridine-synthesis |
The De Kimpe aziridine synthesis is a name reaction of organic chemistry, for the generation of aziridines by the reaction of α-chloroimines with nucleophiles such as hydride,[1] cyanide, or Grignard reagents.[2][3]
The De Kimpe aziridine synthesis is suitable for both aldimines and ketimines, particularly those with two alkyl substituents on the α-carbon (Thorpe-Ingold effect).[4]
