Decernotinib

Decernotinib is an inhibitor of Janus kinase 3 (JAK3) discovered through a process of inhouse screening of a chemical compound library. Decernotinib also had the name VX-509 in development phase. It is an experimental drug with high selectivity for JAK3, which demonstrates good efficacy in vivo in the rat host versus graft model (HvG). It has been studied in clinical trials at Vertex Pharmaceuticals,^[1] and while it was not approved for clinical use it continues to be used for research.^[2][3][4]

CAS Number

• 944842-54-0

PubChem CID

• 59422203

ChemSpider

• 30843790

UNII

• MZK2GP0RHK

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Decernotinib

Identifiers
IUPAC name (2R)-2-Methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-(2,2,2-trifluoroethyl)butanamide
CAS Number	944842-54-0
PubChem CID	59422203
ChemSpider	30843790
UNII	MZK2GP0RHK
KEGG	D10585
CompTox Dashboard (EPA)	DTXSID70241504
Chemical and physical data
Formula	C18H19F3N6O
Molar mass	392.386 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC[C@](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3
InChI InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1 Key:ASUGUQWIHMTFJL-QGZVFWFLSA-N

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