Deoxysarpagine hydroxylase
Class of enzymes
From Wikipedia, the free encyclopedia
Deoxysarpagine hydroxylase (EC 1.14.14.136) is an enzyme that catalyzes the chemical reaction
10-deoxysarpagine
O2
H2O
sarpagine
| Deoxysarpagine hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.136 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme is a cytochrome P450 protein containing heme, isolated from Rauvolfia species. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. The systematic name of this enzyme class is 10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating). It is also called DOSH. The compounds are indole alkaloids.[1][2]
