The museum is divided into four main pavilions with different themes.[3]
Due to factors such as erosion, the different geological structures have made it simpler to discover fossils in the Mexican deserts which have helped to understand more about these forms of life. The collections and exhibitions shown in this pavilion explore the origins of deserts. Also it is possible to appreciate the mineral wealth where coal is the main mineral extracted in this region. The museum also features dinosaurs which lived in the region: Isauria, Sabinosaurio, Quetzalcoatlus and a Tyrannosaurus rex 17 meters long and five meters high, as well as interactive displays about recent discoveries in the palaeontology of the region
This pavilion shows mainly the habits and rituals of the nomads who lived in this region. It is possible to appreciate the petroglyphs and rupestrian paintings, which are very characteristic of this area.
This pavilion in particular was inaugurated on 4 August 2005. It displays the traces of the evolution along the last 12,000 years, as during this period the biodiversity in this region witnessed mammoths, saber-toothed cats, short-faced bears and gomphotheres.
This interactive pavilion traces 70 million years backwards, showing the greater quantity of fauna through a biodome. Also it has a laboratory of herpetology where specialists work with the museum's reptiles.
