Desglymidodrine
Antihypotensive agent active metabolite
From Wikipedia, the free encyclopedia
Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine.[2][3][4] It acts as a selective α1-adrenergic receptor agonist.[2][3][4] Desglymidodrine is formed from midodrine via deglycination.[2][3][4]
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| Other names | Deglymidodrine; ST-1059; 2,5-Dimethoxy-β-hydroxyphenethylamine; β-Hydroxy-2C-H |
| Drug class | α1-Adrenergic receptor agonist; Antihypotensive agent; Vasopressor |
| Pharmacokinetic data | |
| Elimination half-life | 2–4 hours[1] |
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| ECHA InfoCard | 100.322.299 |
| Chemical and physical data | |
| Formula | C10H15NO3 |
| Molar mass | 197.234 g·mol−1 |
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Pharmacology
Pharmacokinetics
The elimination half-life of desglymidodrine is 2 to 4 hours.[1]
Chemistry
Desglymidodrine, also known as 3,6-dimethoxy-β-hydroxy-2-phenylethylamine, is a substituted phenethylamine derivative.[5][6]
Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.[7][8] The predicted log P of desglymidodrine ranges from -0.01 to 0.15.[5][6]
An analogue of desglymidodrine is dimetofrine (3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine).