The promoted physicist worked in medical research and teaching in Germany, later in his specialty in cancer research and as a lecturer in the Middle East. In 1991 he became human resources manager at DMG. In 2000, he took over the management of Manfred A. Bluthardt.
Since 1996 Detlef Blöcher is also an associate of the World Evangelical Alliance (WEA), on whose behalf he has directed several missiological research projects. In this context specialized articles about the studies REMAP I and REMAP II, dealing with the methods, effectiveness and limitations of modern Christian mission work, have been published.[2][3][4] In addition Blöcher is an expert on Christian missions and development aid and has published numerous specialist articles in Christian journals such as the magazine Entscheidung and idea spectrum.
Since 2004 Blöcher has also been active as chairman of the "Arbeitsgemeinschaft Evangelikaler Missionen" (AEM, Arbeitsgemeinschaft Evangelical Missions).[5]