Diaminobutyrate acetyltransferase

Diaminobutyrate acetyltransferase (EC 2.3.1.178) is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (S)-2,4-diaminobutyric acid and acetyl-CoA. Its products are N(4)-acetyl-L-2,4-diaminobutyric acid and coenzyme A.^[1][2] The enzyme has been characterised in a number of organisms including Halomonas elongata, Methylomicrobium alcaliphilum and Bacillus pasteurii. The product of the reaction is converted to ectoine by the enzyme ectoine synthase in these species.^[3][4][5]

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase. Other names in common use include L-2,4-diaminobutyrate acetyltransferase, L-2,4-diaminobutanoate acetyltransferase, EctA, diaminobutyric acid acetyltransferase, DABA acetyltransferase, 2,4-diaminobutanoate acetyltransferase, DAB acetyltransferase, DABAcT, and acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase.^[6]