Dimethylglycine N-methyltransferase
From Wikipedia, the free encyclopedia
Dimethylglycine N-methyltransferase (EC 2.1.1.161, BsmB, DMT) is an enzyme with systematic name S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming).[1] This enzyme catalyses the following chemical reaction
The enzyme adds a methyl group to N.N-dimethylglycine, giving the product betaine, trimethylglycine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from the cyanobacterium, Synechococcus sp. WH8102.[2] Unlike the related enzyme, sarcosine/dimethylglycine N-methyltransferase, sarcosine is not a substrate.[1]
