Dimetindene

Chemical compound From Wikipedia, the free encyclopedia

Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation[1] selective H1 antagonist.[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally[3] passes across the blood–brain barrier.

Trade namesFenistil
ATC code
Quick facts Clinical data, Trade names ...
Dimetindene
Clinical data
Trade namesFenistil
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral, topical
ATC code
Legal status
Legal status
Identifiers
  • N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.024.622 Edit this at Wikidata
Chemical and physical data
FormulaC20H24N2
Molar mass292.426 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
  • InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 checkY
  • Key:MVMQESMQSYOVGV-UHFFFAOYSA-N checkY
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Dimetindene is also an M2 receptor antagonist.[4]

It was patented in 1958 and came into medical use in 1960.[5]

Medical use

Dimetindene is used orally and topically as an antipruritic.[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as hay fever.

It is commonly formulated as its maleic acid salt, dimethindene maleate.

Names

It is sold under the brand name Fenistil among others.

References

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