Dioxopromethazine

Dioxopromethazine
Clinical data
Trade names	Prothanon
Other names	9,9-Dioxopromethazine
Drug class	antihistamine; antitussive
Legal status
Legal status	generally not controlled;
Identifiers
	IUPAC name 1-(5,5-dioxophenothiazin-10-yl)-N,N-dimethylpropan-2-amine;
CAS Number	13582-96-2 13754-56-8; 13582-97-3;
PubChem CID	63031;
ChemSpider	56726;
UNII	6OOT1MR6XS;
ChEMBL	ChEMBL3580712;
CompTox Dashboard (EPA)	DTXSID80929821 ;
Chemical and physical data
Formula	C17H20N2O2S
Molar mass	316.42 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C31)N(C)C;
	InChI InChI=1S/C17H20N2O2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)22(20,21)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3; Key:FDXKCOBAFGSMDJ-UHFFFAOYSA-N;

Other names9,9-Dioxopromethazine

Dioxopromethazine, sold under the trade name Prothanon, is an phenothiazine antihistamine, which is widely used in clinical practice in the form of a racemate for the treatment of respiratory diseases or allergic diseases, commonly used in the form of hydrochloride or hydrogels, especially as eye drops^[1]^[2] It was first developed and synthesized in the German Democratic Republic in 1967 and later introduced into clinical practice. It was widely used from the 1970s to 1990s, after which there was a proposal to remove Dioxopromethazine from the pharmaceutical market.^[1]^[3]

Pharmacodynamics