Dipeptidase 3

Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.^[5]

AliasesDPEP3, MBD3, dipeptidase 3

External IDsOMIM: 609926; MGI: 1919104; GeneCards: DPEP3

Chr.Chromosome 16 (human)^[1]

End67,980,549 bp^[1]

Quick facts DPEP3, Identifiers ...

DPEP3
Identifiers
Aliases	DPEP3, MBD3, dipeptidase 3
External IDs	OMIM: 609926; MGI: 1919104; GeneCards: DPEP3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,975,663 bp[1] End 67,980,549 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,700,145 bp[2] End 106,706,061 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle sperm blood granulocyte spleen bone marrow muscle of thigh Top expressed in spermatocyte spermatid seminiferous tubule primary oocyte morula morula secondary oocyte blastocyst Gonadal ridge zygote More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloexopeptidase activity dipeptidyl-peptidase activity metallopeptidase activity hydrolase activity metal ion binding dipeptidase activity Cellular component anchored component of membrane membrane acrosomal vesicle plasma membrane Biological process male meiotic nuclear division meiosis proteolysis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 64180 71854 Ensembl ENSG00000141096 ENSMUSG00000031898 UniProt Q9H4B8 Q9DA79 RefSeq (mRNA) NM_022357 NM_001129758 NM_001370198 NM_027960 RefSeq (protein) NP_001123230 NP_001357127 NP_082236 Location (UCSC) Chr 16: 67.98 – 67.98 Mb Chr 8: 106.7 – 106.71 Mb PubMed search [3] [4]
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This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[6]