Diphenidol

Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada.

AHFS/Drugs.comMicromedex Detailed Consumer Information

Routes of
administrationOral

ATC code

• none

Elimination half-life4 hours

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Diphenidol

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral
ATC code	none
Pharmacokinetic data
Elimination half-life	4 hours
Identifiers
IUPAC name 1,1-di(phenyl)-4-piperidin-1-ylbutan-1-ol
CAS Number	972-02-1 Y
PubChem CID	9175
IUPHAR/BPS	7163
DrugBank	DB01231 Y
ChemSpider	2947 Y
UNII	NQO8R319LY
KEGG	D03858 Y
ChEBI	CHEBI:4638 Y
ChEMBL	ChEMBL936 Y
CompTox Dashboard (EPA)	DTXSID3022950
ECHA InfoCard	100.012.310
Chemical and physical data
Formula	C21H27NO
Molar mass	309.453 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC(c1ccccc1)(c2ccccc2)CCCN3CCCCC3
InChI InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2 Y Key:OGAKLTJNUQRZJU-UHFFFAOYSA-N Y
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Although the mechanism of action of diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M₁, M₂, M₃ and M₄. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. A series of selective mACh-receptor antagonists based on the diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials.^[1]