From 2015 until the time of his election, Mykysha was deputy mayor of Merefa for functions of the city's executive bodies.[1]
Mykysha ran in the 2019 Ukrainian parliamentary election as the candidate of Servant of the People for People's Deputy of Ukraine in Ukraine's 181st electoral district. He was successfully elected, defeating runner-up Valeria Murayeva (an independent) with 38.05% of the vote to Murayeva's 23.01%.[2] At the time of the election, Mykysha was himself an independent. In the Verkhovna Rada (Ukraine's parliament), Mykysha joined the Servant of the People faction and the Verkhovna Rada Committee on Organising State Power, Local Self-Government, Regional Development, and Urban Planning.[3]
In 2019, according to a report by anti-corruption non-governmental organisation Chesno, Mykysha voted against bills more than any other People's Deputy within the Servant of the People faction.[3] According to informational portal Slovo i Dilo, as of 15 March 2021 Mykysha had fulfilled 22% of his 32 electoral promises, with the only promise that failed outright being a promise to attend all meetings of the Verkhovna Rada.[4] Among his fulfilled promises included support for raising defence spending to 5% of Ukraine's gross domestic product, an independent audit of Ukraine's highway system, and to reduce the level of corruption in the office of Prosecutor General of Ukraine.[5]
On 8 November 2021, Mykysha joined former Chairman of the Verkhovna Rada Dmytro Razumkov and 23 other People's Deputies in forming the Smart Politics political party. Despite this, however, he has not left the Servant of the People faction in the Verkhovna Rada.[3]