Dolichol kinase
Protein-coding gene in the species Homo sapiens
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In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction
- CTP + dolichol CDP + dolichyl phosphate
| dolichol kinase | |||||||||
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| Identifiers | |||||||||
| EC no. | 2.7.1.108 | ||||||||
| CAS no. | 71768-07-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| DOLK | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | DOLK, CDG1M, DK, DK1, SEC59, TMEM15, dolichol kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610746; MGI: 2677836; HomoloGene: 8940; GeneCards: DOLK; OMA:DOLK - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.
This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in N-glycan biosynthesis.
In humans dolichol kinase is encoded by the DOLK gene.[5][6][7]
Function
Dolichyl monophosphate is an essential glycosyl carrier lipid for C- and O-mannosylation and N-glycosylation of proteins and for biosynthesis of glycosylphosphatidylinositol anchors in endoplasmic reticulum (ER). Dolichol kinase catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate biosynthesis.[8]
Clinical significance
Mutations in DOLK cause a subtype of the congenital disorders of glycosylation, DOLK-CDG (CDG-Im).[9]
