Dolichol kinase

DOLK
Identifiers
Aliases	DOLK, CDG1M, DK, DK1, SEC59, TMEM15, dolichol kinase
External IDs	OMIM: 610746; MGI: 2677836; GeneCards: DOLK
Enzyme activity
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,947,603 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,176,346 bp
RNA expression pattern
	Top expressed in
	gonad; ; stromal cell of endometrium; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; islet of Langerhans; ; testicle; ; gingival epithelium; ; parotid gland; ; nasal epithelium;
	Top expressed in
	interventricular septum; ; brown adipose tissue; ; external carotid artery; ; internal carotid artery; ; tunica adventitia of aorta; ; white adipose tissue; ; vastus lateralis muscle; ; intercostal muscle; ; subcutaneous adipose tissue; ; motor neuron;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; kinase activity; dolichol kinase activity;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	dolichyl diphosphate biosynthetic process; phosphorylation; protein glycosylation; dolichyl monophosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22845
	227697
	ENSG00000175283
	ENSMUSG00000075419
	Q9UPQ8
	Q8R2Y3
	NM_014908
	NM_177648
	NP_055723
	NP_808316
	Wikidata
View/Edit Human	View/Edit Mouse

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dolichol kinase
dolichol kinase
Identifiers
EC no.	2.7.1.108
CAS no.	71768-07-5
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction

CTP + dolichol

\rightleftharpoons

CDP + dolichyl phosphate

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AliasesDOLK, CDG1M, DK, DK1, SEC59, TMEM15, dolichol kinase

External IDsOMIM: 610746; MGI: 2677836; GeneCards: DOLK

Chr.Chromosome 9 (human)^[1]

End128,947,603 bp^[1]

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Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in N-glycan biosynthesis.

In humans dolichol kinase is encoded by the DOLK gene.^[5]^[6]^[7]

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Dolichol kinase

Function

Clinical significance

See also

References

Further reading

External links

Related Articles

Related Articles

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment"

"Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae"

"A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy"

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"

"DNA sequence and analysis of human chromosome 9"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"