DopAmide

Dopaminergic agent From Wikipedia, the free encyclopedia

DopAmide, or L-DopAmide, is a synthetic levodopa (L-DOPA) analogue that can serve as a levodopa and dopamine prodrug and is of potential interest in the treatment of Parkinson's disease.[1][2][3] DopAmide has an amide rather than the carboxyl group of L-DOPA,[2][3] which imparts greater water solubility.[1][2][3] The amide is hydrolyzed back to the acid by aminopeptidase enzymes.[1][2][3]

Other namesL-DopAmide; 3-Hydroxytyrosinamide
CAS Number
Quick facts Clinical data, Other names ...
DopAmide
Clinical data
Other namesL-DopAmide; 3-Hydroxytyrosinamide
Drug classMonoamine precursor; Dopamine receptor agonist
Identifiers
  • 2-amino-3-(3,4-dihydroxyphenyl)propanamide
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC9H12N2O3
Molar mass196.206 g·mol−1
3D model (JSmol)
  • C1=CC(=C(C=C1CC(C(=O)N)N)O)O
  • InChI=1S/C9H12N2O3/c10-6(9(11)14)3-5-1-2-7(12)8(13)4-5/h1-2,4,6,12-13H,3,10H2,(H2,11,14)
  • Key:DXOJUCNAHCVBRU-UHFFFAOYSA-N
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