Spohr initially performed music composed by Backofen, but after her marriage, Louis Spohr composed for her.[5] Between June 1806 and October 1807, Spohr bought a harp from Paris using part of her dowry.[2] From 1810 to 1812, Spohr was principal harpist at the court of Gotha, where she taught the Duke's daughter, Princess Louise of Saxe-Gotha-Altenburg.[2] Spohr and her husband toured Germany, Switzerland, and Russia, performing with a number of musical orchestras.
In 1820, after experiencing difficulties adapting to a new harp with a double-action pedal mechanism,[7] Spohr retired from playing harp. After her retirement, she became interested in piano.[8]
Spohr died in 1834 following a fever. Although she seems “not to have composed any music herself," Rensch says that "she inspired the composition of some of the first major ensemble music for harp and violin."