Ivonescimab
Monoclonal antibody
From Wikipedia, the free encyclopedia
Ivonescimab is a humanized bispecific monoclonal antibody currently being trialed for use against non-small-cell lung cancer. Developed by Akeso, it has been approved in China for the treatment of epidermal growth factor receptor-mutated locally advanced or metastatic non-squamous NSCLC in patients who have progressed past tyrosine kinase inhibitor therapy,[1] and is undergoing clinical trials elsewhere.
| Monoclonal antibody | |
|---|---|
| Type | ? |
| Source | Humanized (from hamster) |
| Target | PD-1, VEGF-A |
| Clinical data | |
| Other names | AK112 |
| Pharmacokinetic data | |
| Elimination half-life | 6-7 days |
| Identifiers | |
| CAS Number | |
| PubChem SID | |
| DrugBank | |
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Mechanism of action
Ivonescimab prevents tumor proliferation and angiogenesis by inhibiting programmed cell death protein 1 and vascular endothelial growth factor A, respectively.[2]
Research
Ivonescimab so far has only completed trials in Chinese patients,[3] and is currently undergoing phase III trials in the United States for the treatment of non-squamous non-small-cell lung cancer and advanced NSCLC.[4]
Society and culture
The initial success of ivonescimab in trials is compared to already-approved drugs such as Merck & Co.'s Keytruda (pembrolizumab); its success has been described as important for the pharmaceutical industry in China.[5]
