Drosophila Genetic Reference Panel
From Wikipedia, the free encyclopedia
Drosophila Genetic Reference Panel (DGRP) is a suite of Drosophila melanogaster lines derived from an out-crossed population in Raleigh, North Carolina. The founders of these lineages were collected from the Raleigh State Farmer's Market[1] 35°45′51″N 78°39′47″W / 35.764254°N 78.662935°W. The suite consists of 205 fully sequenced lines which have been inbred to near homozygosity. The primary goal of the DGRP is to provide a common set of strain for quantitative genetics research in Drosophila. Each researcher who uses the lines from the DGRP will have access to other researchers' data, which will be stored in a publicly available database. This allows for analyses to be performed across studies without having to worry about complications arising from different labs using genomically different lines of fruit flies.[2][3]
These lines are useful for performing QTL maps, as every line is fully sequenced. This allows for association mapping to be performed, which looks for genomic regions that are correlated to a phenotype. As labs produce QTL maps a comprehensive picture of the Drosophila genome will emerge with unprecedented resolution. Currently, dozens of quantitative traits are being examined by researchers, including longevity, phototaxis, mating behavior, wing morphology and oviposition site preference.