EDMA
Chemical compound
From Wikipedia, the free encyclopedia
EDMA, also known as 3,4-ethylenedioxy-N-methylamphetamine or as MDMC, is a psychoactive drug of the phenethylamine, amphetamine, and EDxx families.[1][2] It is an analogue of MDMA where the methylenedioxy ring has been replaced by an ethylenedioxy ring.[1][2]
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| Other names | 3,4-Ethylenedioxy-N-methylamphetamine; EDMA; MDMC |
| Routes of administration | Oral[1] |
| Drug class | Psychoactive drug |
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| Duration of action | 3–5 hours[1] |
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| Formula | C12H17NO2 |
| Molar mass | 207.273 g·mol−1 |
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In his book PiHKAL (Phenethylamines I Have Known and Loved), the dose is listed as 150 to 250 mg orally and the duration as 3 to 5 hours.[1] According to Shulgin, EDMA produces only mild effects that included paresthesia, nystagmus, a dozing state, hypnogogic imagery, and colored letters in the peripheral visual field.[1]
It has been found that EDMA acts as a non-neurotoxic serotonin releasing agent with moderately diminished potency relative to MDMA, and with negligible effects on dopamine release.[2] However, subsequent research found that EMDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) with EC50 values of 117 nM for serotonin release, 325 nM for norepinephrine release, and 597 nM for dopamine release in rat brain synaptosomes.[3] Compared to MDMA, EDMA was about half as potent as a serotonin releaser, 4.5-fold less potent as a norepinephrine releaser, and 8-fold less potent as a dopamine releaser.[3] The activities of the individual enantiomers of EDMA have also been assessed.[3]
The chemical synthesis of EDMA has been described.[1]
While commonly referred to as EDMA, Shulgin refers to this compound as both MDMC and EDMA in PiHKAL, calling the former a "Shulgin pet name" for the compound, and stating that the name "doesn't really make sense".[1] MDMC commonly refers to a different analogue of MDMA, methylone.[4]