EF-1502
GABA reuptake inhibitor
From Wikipedia, the free encyclopedia
EF-1502 is a GABA reuptake inhibitor. It could potentially be used to treat seizures.
| Names | |
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| IUPAC name
4-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl-methylamino]-4,5,6,7-tetrahydro-1,2-benzoxazol-3-one | |
| Identifiers | |
3D model (JSmol) |
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| ChEMBL | |
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PubChem CID |
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| Properties | |
| C22H26N2O2S2 | |
| Molar mass | 414.58 g·mol−1 |
| Pharmacology | |
| Drug class | GABA reuptake inhibitor; GABA transporter 1 (GAT-1) inhibitor |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mechanism of action
EF-1502 has been shown to inhibit the type 1 GABA transporter (GAT1)[1] and the sodium and chloride-dependent betaine transporter (BGT-1).[2]
