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EF-1502

GABA reuptake inhibitor From Wikipedia, the free encyclopedia

EF-1502 is a GABA reuptake inhibitor. It could potentially be used to treat seizures.

Quick facts Names, Identifiers ...
EF-1502
Names
IUPAC name
4-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl-methylamino]-4,5,6,7-tetrahydro-1,2-benzoxazol-3-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C22H26N2O2S2/c1-14-9-12-27-20(14)16(21-15(2)10-13-28-21)6-5-11-24(3)17-7-4-8-18-19(17)22(25)23-26-18/h6,9-10,12-13,17H,4-5,7-8,11H2,1-3H3,(H,23,25)
    Key: CUESOMOCKVRNIW-UHFFFAOYSA-N
  • CC1=C(SC=C1)C(=CCCN(C)C2CCCC3=C2C(=O)NO3)C4=C(C=CS4)C
Properties
C22H26N2O2S2
Molar mass 414.58 g·mol−1
Pharmacology
Drug class GABA reuptake inhibitor; GABA transporter 1 (GAT-1) inhibitor
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mechanism of action

EF-1502 has been shown to inhibit the type 1 GABA transporter (GAT1)[1] and the sodium and chloride-dependent betaine transporter (BGT-1).[2]

Potential use

Tests in mice have shown that this compound possesses and anticonvulsant effect due to its GABA reuptake inhibiting properties.[3][4]

References

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