EGR4

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.^[5]

AliasesEGR4, NGFI-C, NGFIC, PAT133, early growth response 4, Early growth response protein 4, AT133

External IDsOMIM: 128992; MGI: 99252; HomoloGene: 1485; GeneCards: EGR4; OMA:EGR4 - orthologs

Chr.Chromosome 2 (human)^[1]

End73,293,701 bp^[1]

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EGR4
Identifiers
Aliases	EGR4, NGFI-C, NGFIC, PAT133, early growth response 4, Early growth response protein 4, AT133
External IDs	OMIM: 128992; MGI: 99252; HomoloGene: 1485; GeneCards: EGR4; OMA:EGR4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.2 Start 73,290,929 bp[1] End 73,293,701 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 37.48 cM Start 85,488,103 bp[2] End 85,490,571 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell gonad Region I of hippocampus proper endothelial cell testicle pancreatic ductal cell putamen Brodmann area 46 nucleus accumbens entorhinal cortex Top expressed in superior frontal gyrus primary visual cortex urethra female urethra male urethra embryo dentate gyrus of hippocampal formation granule cell spermatocyte cerebellar cortex hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding metal ion binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular response to growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1961 13656 Ensembl ENSG00000135625 ENSMUSG00000071341 UniProt Q05215 Q9WUF2 RefSeq (mRNA) NM_001965 NM_020596 RefSeq (protein) NP_001956 NP_065621 Location (UCSC) Chr 2: 73.29 – 73.29 Mb Chr 6: 85.49 – 85.49 Mb PubMed search [3] [4]
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EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors.