EIF2AK3

EIF2AK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4G31, 4G34, 4M7I, 4X7H, 4X7J, 4X7K, 4X7L, 4X7N, 4X7O, 4YZS
Identifiers
Aliases	EIF2AK3, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3
External IDs	OMIM: 604032; MGI: 1341830; HomoloGene: 3557; GeneCards: EIF2AK3; OMA:EIF2AK3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	88,691,518 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	70,882,229 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; mucosa of paranasal sinus; ; Achilles tendon; ; pylorus; ; parotid gland; ; nasal epithelium; ; mucosa of sigmoid colon; ; tibia; ; epithelium of nasopharynx; ; trachea;
	Top expressed in
	submandibular gland; ; lacrimal gland; ; parotid gland; ; granulocyte; ; seminal vesicula; ; calvaria; ; islet of Langerhans; ; lumbar spinal ganglion; ; epithelium of stomach; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; Hsp90 protein binding; nucleotide binding; protein homodimerization activity; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; enzyme binding; protein phosphatase binding; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; perinuclear region of cytoplasm; cytosolic ribosome;
Biological process	skeletal system development; bone mineralization; insulin-like growth factor receptor signaling pathway; negative regulation of translation; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; cellular response to glucose starvation; negative regulation of translation in response to stress; ossification; negative regulation of translational initiation in response to stress; phosphorylation; cellular response to amino acid starvation; chondrocyte development; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; insulin secretion; endoplasmic reticulum organization; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; ER overload response; response to manganese-induced endoplasmic reticulum stress; endoplasmic reticulum unfolded protein response; protein phosphorylation; response to unfolded protein; positive regulation of gene expression; cellular response to cold; peptidyl-serine phosphorylation; angiogenesis; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; protein autophosphorylation; positive regulation of vascular endothelial growth factor production; positive regulation of transcription by RNA polymerase I; protein homooligomerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of myelination; regulation of translation; calcium-mediated signaling; endocrine pancreas development; positive regulation of protein localization to nucleus; regulation of translational initiation by eIF2 alpha phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9451
	13666
	ENSG00000172071
	ENSMUSG00000031668
	Q9NZJ5
	Q9Z2B5
	NM_001313915; NM_004836
	NM_010121; NM_001313918
	NP_001300844; NP_004827
	NP_001300847; NP_034251
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.^[5]^[6]^[7]^[8]