EIF2AK4

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.^[5][6]

AliasesEIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4

External IDsOMIM: 609280; MGI: 1353427; GeneCards: EIF2AK4

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 15 (human)^[1]

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EIF2AK4
Identifiers
Aliases	EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
External IDs	OMIM: 609280; MGI: 1353427; GeneCards: EIF2AK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UKX, 4OTN
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.1 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 39,934,115 bp[1] End 40,035,591 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 118,219,099 bp[2] End 118,305,715 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary bone marrow cell stromal cell of endometrium synovial membrane tibia Achilles tendon Brodmann area 9 nucleus accumbens left uterine tube caudate nucleus Top expressed in medullary collecting duct secondary oocyte primary oocyte zygote saccule otic placode Paneth cell external carotid artery epithelium of lens internal carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity tRNA binding kinase activity protein serine/threonine kinase activity RNA binding ATP binding eukaryotic translation initiation factor 2alpha kinase activity Cellular component cytoplasm polysome cytosolic ribosome Biological process positive regulation of translational initiation in response to starvation adaptive immune response negative regulation of neuron differentiation positive regulation of long-term synaptic potentiation positive regulation of adaptive immune response negative regulation of translational initiation in response to stress negative regulation of translational initiation phosphorylation immune system process cellular response to UV cellular response to amino acid starvation negative regulation of CREB transcription factor activity regulation of feeding behavior learning nervous system development viral translation neuron projection extension protein phosphorylation cellular response to cold long-term memory defense response to virus cellular response to leucine starvation eiF2alpha phosphorylation in response to endoplasmic reticulum stress induction by virus of host autophagy protein autophosphorylation cell cycle negative regulation by host of viral genome replication viral process regulation of translation regulation of translational initiation positive regulation of defense response to virus by host T cell activation involved in immune response DNA damage checkpoint signaling regulation of translational initiation by eIF2 alpha phosphorylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 440275 27103 Ensembl ENSG00000128829 ENSMUSG00000005102 UniProt Q9P2K8 Q9QZ05 RefSeq (mRNA) NM_001013703 NM_001177806 NM_013719 NM_001355383 RefSeq (protein) NP_001013725 NP_001171277 NP_038747 NP_001342312 Location (UCSC) Chr 15: 39.93 – 40.04 Mb Chr 2: 118.22 – 118.31 Mb PubMed search [3] [4]
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EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM]^[6]