EIF2C1

AGO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SI2, 1SI3, 4KRE, 4KRF, 4KXT
Identifiers
Aliases	AGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
External IDs	OMIM: 606228; MGI: 2446630; HomoloGene: 81826; GeneCards: AGO1; OMA:AGO1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	35,930,532 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	126,362,376 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; visceral pleura; ; tendon of biceps brachii; ; parietal pleura; ; ventricular zone; ; hair follicle; ; monocyte; ; internal globus pallidus; ; tibia; ; stromal cell of endometrium;
	Top expressed in
	Rostral migratory stream; ; superior cervical ganglion; ; ventricular zone; ; ganglionic eminence; ; vestibular labyrinth; ; ciliary body; ; vestibular sensory epithelium; ; otolith organ; ; iris; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II complex binding; miRNA binding; endoribonuclease activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; single-stranded RNA binding; RNA binding; nucleic acid binding; double-stranded RNA binding;
Cellular component	cytoplasm; polysome; cytosol; RISC complex; P-body; nucleoplasm; RISC-loading complex; nucleus; ribonucleoprotein complex;
Biological process	mRNA destabilization-mediated gene silencing by siRNA; regulation of transcription, DNA-templated; transcription, DNA-templated; pre-miRNA processing; nuclear-transcribed mRNA catabolic process; positive regulation of gene expression; RNA interference; miRNA-mediated gene silencing by inhibition of translation; RNA secondary structure unwinding; mRNA destabilization-mediated gene silencing by miRNA; miRNA metabolic process; regulation of translation; positive regulation of transcription by RNA polymerase II; production of miRNAs involved in gene silencing by miRNA; positive regulation of NIK/NF-kappaB signaling; Wnt signaling pathway, calcium modulating pathway; gene silencing; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; negative regulation of gene expression; negative regulation of angiogenesis; RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	26523
	236511
	ENSG00000092847
	ENSMUSG00000041530
	Q9UL18
	Q8CJG1
	NM_012199; NM_001317122; NM_001317123
	NM_153403; NM_001317173; NM_001317174; NM_001378879
	NP_001304051; NP_001304052; NP_036331
	NP_001304102; NP_001304103; NP_700452; NP_001365808
	Wikidata
View/Edit Human	View/Edit Mouse

Protein argonaute-1 is a protein that in humans is encoded by the EIF2C1 gene.^[5]^[6]^[7]

PDBOrtholog search: PDBe RCSB

AliasesAGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1

External IDsOMIM: 606228; MGI: 2446630; HomoloGene: 81826; GeneCards: AGO1; OMA:AGO1 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts AGO1, Available structures ...

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[7]

[1]

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[4]

EIF2C1

Function

References

Further reading

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