EME1

EME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S
Identifiers
Aliases	EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1
External IDs	OMIM: 610885; MGI: 3576783; HomoloGene: 16123; GeneCards: EME1; OMA:EME1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,381,483 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,544,790 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; corpus epididymis; ; tendon of biceps brachii; ; mucosa of ileum; ; pancreatic ductal cell; ; oocyte; ; endothelial cell; ; right testis; ; left testis; ; secondary oocyte;
	Top expressed in
	lateral part of occipital bone; ; genital tubercle; ; tail of embryo; ; epiblast; ; somite; ; yolk sac; ; thyroid cartilage; ; maxillary prominence; ; mandibular prominence; ; sphenoid bone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; endonuclease activity; nuclease activity; protein binding; hydrolase activity; metal ion binding; endodeoxyribonuclease activity; crossover junction endodeoxyribonuclease activity;
Cellular component	nucleolus; nucleoplasm; nucleus; Holliday junction resolvase complex;
Biological process	cellular response to DNA damage stimulus; DNA recombination; interstrand cross-link repair; nucleic acid phosphodiester bond hydrolysis; response to intra-S DNA damage checkpoint signaling; DNA repair; resolution of meiotic recombination intermediates; double-strand break repair; replication fork processing; mitotic intra-S DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	146956
	268465
	ENSG00000154920
	ENSMUSG00000039055
	Q96AY2
	Q8BJW7
	NM_001166131; NM_152463
	NM_177752; NM_001379688
	NP_001159603; NP_689676
	NP_808420; NP_001366617
	Wikidata
View/Edit Human	View/Edit Mouse

Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene.^[5]^[6] It forms a complex with MUS81 which resolves Holliday junctions. In mammalian cells the EME1/MUS81 protein complex is redundant for DNA damage repair with GEN1 endonuclease.^[7] In mice, EME1/MUS81 and GEN1 redundantly contribute to Holliday junction processing. When homozygous mutations of Gen1 and Eme1 were combined in mice the result was synthetic lethality at an early embryonic stage.^[7] Homozygosity for Gen1 mutations did not cause a DNA repair deficiency in mice. But when mice were both homozygous mutant for Gen1 and also heterozygous for an Emc1 mutation, they showed increased sensitivity to DNA damaging agents. This finding, indicated a redundant role of GEN1 and EME1 in DNA repair. Gen1 and Emc1 were also shown to have redundant roles in meiotic recombination.^[7]