EML4

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.^[5]

AliasesEML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4

External IDsOMIM: 607442; MGI: 1926048; GeneCards: EML4

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

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EML4
Identifiers
Aliases	EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4
External IDs	OMIM: 607442; MGI: 1926048; GeneCards: EML4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CGC
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 42,169,353 bp[1] End 42,332,548 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 83,658,360 bp[2] End 83,787,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia jejunal mucosa visceral pleura tonsil mucosa of sigmoid colon epithelium of nasopharynx duodenum rectum pylorus mucosa of paranasal sinus Top expressed in hand maxillary prominence mandibular prominence molar primitive streak abdominal wall Gonadal ridge secondary oocyte migratory enteric neural crest cell renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding molecular function Cellular component cytoplasm microtubule cytoskeleton membrane microtubule cytoskeleton mitotic spindle Biological process microtubule-based process mitotic cell cycle microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 27436 78798 Ensembl ENSG00000143924 ENSMUSG00000032624 UniProt Q9HC35 Q3UMY5 RefSeq (mRNA) NM_001145076 NM_019063 NM_001114361 NM_001114362 NM_001286567 NM_199466 NM_001357886 NM_001379373 NM_001379374 RefSeq (protein) NP_001138548 NP_061936 NP_001107833 NP_001107834 NP_001273496 NP_955760 NP_001344815 NP_001366302 NP_001366303 Location (UCSC) Chr 2: 42.17 – 42.33 Mb Chr 17: 83.66 – 83.79 Mb PubMed search [3] [4]
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This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.^[6]