ENSA (gene)

ENSA
Identifiers
Aliases	ENSA, ARPP-19e, endosulfine alpha
External IDs	OMIM: 603061; MGI: 1891189; HomoloGene: 37924; GeneCards: ENSA; OMA:ENSA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,629,612 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,539,413 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; prefrontal cortex; ; skin of abdomen; ; gingival epithelium; ; Brodmann area 10; ; right frontal lobe; ; human penis; ; skin of leg; ; vulva; ; tendon of biceps brachii;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; neural layer of retina; ; prefrontal cortex; ; temporal muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; supraoptic nucleus; ; digastric muscle; ; sternocleidomastoid muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; potassium channel inhibitor activity; signaling receptor binding; protein binding; ion channel inhibitor activity; phosphatase inhibitor activity; protein phosphatase inhibitor activity; protein phosphatase regulator activity;
Cellular component	nucleoplasm; cytoplasm;
Biological process	cell division; cell cycle; G2/M transition of mitotic cell cycle; response to glucose; response to nutrient; regulation of insulin secretion; negative regulation of catalytic activity; negative regulation of protein dephosphorylation; mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	2029
	56205
	ENSG00000143420
	ENSMUSG00000038619
	O43768
	P60840
NM_207168; NM_004436; NM_207042; NM_207043; NM_207044;
	NM_207045; NM_207046; NM_207047
	NM_001026212; NM_019561
NP_004427; NP_996925; NP_996926; NP_996927; NP_996928;
	NP_996929; NP_996930; NP_997051
	NP_001021383; NP_062507
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene.^[5]^[6]

AliasesENSA, ARPP-19e, endosulfine alpha

External IDsOMIM: 603061; MGI: 1891189; HomoloGene: 37924; GeneCards: ENSA; OMA:ENSA - orthologs

Chr.Chromosome 1 (human)^[1]

End150,629,612 bp^[1]

Quick facts Identifiers, Aliases ...

Close

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

ENSA (gene)

References

Further reading

Related Articles

Related Articles

"Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties"

"Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians"

"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"

"Large-scale mapping of human protein–protein interactions by mass spectrometry"