EPB49

DMTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QZP, 1ZV6
Identifiers
Aliases	DMTN, DMT, EPB49, dematin actin binding protein
External IDs	OMIM: 125305; MGI: 99670; HomoloGene: 1496; GeneCards: DMTN; OMA:DMTN - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,082,527 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,636,048 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 10; ; nucleus accumbens; ; amygdala; ; Brodmann area 9; ; caudate nucleus; ; right hemisphere of cerebellum;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; fetal liver hematopoietic progenitor cell; ; entorhinal cortex; ; perirhinal cortex; ; primary motor cortex; ; prefrontal cortex; ; olfactory tubercle; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	spectrin binding; protein binding; actin binding; signaling receptor binding; protein self-association; actin filament binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; cortical cytoskeleton; plasma membrane; platelet dense tubular network membrane; cell projection membrane; actin filament; actin cytoskeleton; spectrin-associated cytoskeleton; perinuclear region of cytoplasm; endomembrane system; cytoskeleton; postsynaptic density; cytoplasmic vesicle;
Biological process	negative regulation of cell-substrate adhesion; regulation of lamellipodium assembly; cellular response to calcium ion; regulation of filopodium assembly; actin filament reorganization; regulation of actin cytoskeleton organization; negative regulation of peptidyl-threonine phosphorylation; positive regulation of wound healing; actin filament bundle assembly; positive regulation of substrate adhesion-dependent cell spreading; negative regulation of protein targeting to membrane; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of blood coagulation; calcium-mediated signaling using extracellular calcium source; cytoskeleton organization; actin filament capping; transmembrane transport; negative regulation of peptidyl-serine phosphorylation; positive regulation of integrin-mediated signaling pathway; protein secretion by platelet; negative regulation of substrate adhesion-dependent cell spreading; calcium-mediated signaling using intracellular calcium source; positive regulation of fibroblast migration; negative regulation of focal adhesion assembly; actin cytoskeleton organization; positive regulation of platelet aggregation; cellular response to cAMP; erythrocyte development; regulation of cell shape; protein-containing complex assembly; lamellipodium assembly;
	Sources:Amigo / QuickGO
Orthologs
	2039
	13829
	ENSG00000158856
	ENSMUSG00000022099
	Q08495
	Q9WV69
NM_001114135; NM_001114136; NM_001114137; NM_001114138; NM_001114139;
	NM_001302816; NM_001302817; NM_001978; NM_001323378; NM_001323380; NM_001323381; NM_001323382; NM_001323383; NM_001323384; NM_001323385; NM_001323387; NM_001323388; NM_001323389; NM_001323390; NM_001323391; NM_001323392; NM_001323393; NM_001323394; NM_001323395; NM_001323396; NM_001323397; NM_001323398; NM_001323399; NM_001323400; NM_001323401; NM_001323379; NM_001387723; NM_001387726; NM_001387727; NM_001387728; NM_001387730; NM_001387732; NM_001387734; NM_001387735; NM_001387736; NM_001387737; NM_001387742; NM_001387743; NM_001387744; NM_001387745; NM_001387750; NM_001387751; NM_001387752; NM_001387753; NM_001387754; NM_001387755; NM_001387756; NM_001387757
NM_001252662; NM_001252663; NM_001252664; NM_001252665; NM_001252666;
	NM_013514; NM_001360024; NM_001360025; NM_001360026; NM_001360027; NM_001360028; NM_001360029; NM_001360030
NP_001107607; NP_001107608; NP_001107609; NP_001107610; NP_001107611;
	NP_001289745; NP_001289746; NP_001310307; NP_001310308; NP_001310309; NP_001310310; NP_001310311; NP_001310312; NP_001310313; NP_001310314; NP_001310316; NP_001310317; NP_001310318; NP_001310319; NP_001310320; NP_001310321; NP_001310322; NP_001310323; NP_001310324; NP_001310325; NP_001310326; NP_001310327; NP_001310328; NP_001310329; NP_001310330; NP_001969
NP_001239591; NP_001239592; NP_001239593; NP_001239594; NP_001239595;
	NP_038542; NP_001346953; NP_001346954; NP_001346955; NP_001346956; NP_001346957; NP_001346958; NP_001346959
	Wikidata
View/Edit Human	View/Edit Mouse