ERG3

From Wikipedia, the free encyclopedia

ERG3 or sterol C-5 desaturase is a fungal enzyme originally from Saccharomyces cerevisiae, the human ortholog of ERG3 is SC5D.[1] ERG3 localizes to both the endoplasmic reticulum and vesicles,[2][3] catalyzes the C5(6)-dehydrogenation of episterol to 5-dehydroepisterol, 5-Dehydroepisterol will be further converted into ergosterol.[4][5]

The precise structural details of C-5 sterol desaturase substrates vary across eukaryotes. Shown below the reaction scheme are three possible distal groups along with biosynthetic pathways and species they are found in.[6]
OrganismSaccharomyces cerevisiae
SymbolERG3
Alt. symbolsSC5D, SYR1
Entrez850745
Quick facts Sterol C-5 desaturase, Identifiers ...
Sterol C-5 desaturase
Identifiers
OrganismSaccharomyces cerevisiae
SymbolERG3
Alt. symbolsSC5D, SYR1
Entrez850745
HomoloGene5044
RefSeq (mRNA)NM_001181943
Other data
EC number1.14.19.20
ChromosomeXII: 0.25 - 0.25 Mb
Close

See also

References

Related Articles

Wikiwand AI