ETX0462

ETX0462
Identifiers
	IUPAC name [(1R,7S)-7-(N-hydroxy-N'-methylcarbamimidoyl)-5-methyl-9-oxo-4,5,8,10-tetrazatricyclo[6.2.1.02,6]undeca-2(6),3-dien-10-yl] hydrogen sulfate;
PubChem CID	135376294;
ChemSpider	131615996;
Chemical and physical data
Formula	C10H14N6O6S
Molar mass	346.32 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN=C([C@@H]1C2=C(C=NN2C)[C@@H]3CN1C(=O)N3OS(=O)(=O)O)NO;
	InChI InChI=1S/C10H14N6O6S/c1-11-9(13-18)8-7-5(3-12-14(7)2)6-4-15(8)10(17)16(6)22-23(19,20)21/h3,6,8,18H,4H2,1-2H3,(H,11,13)(H,19,20,21)/t6-,8-/m0/s1; Key:HXTQIYBHDSBEJG-XPUUQOCRSA-N;

ETX0462 is an experimental antibiotic drug which acts both as a β-lactamase inhibitor and also has separate antibiotic activity in its own right. It is active against a range of drug-resistant bacteria of concern including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Burkholderia cepacia. While ETX0462 is still in pre-clinical research and has not yet reached clinical trials, it was hailed as a significant advance as it represents an example of a completely new structural class of antibiotics, so even if this particular molecule does not get developed for medical use it is likely that related compounds will continue to be developed.^[1]^[2]^[3]

PubChem CID

135376294

ChemSpider

131615996

FormulaC₁₀H₁₄N₆O₆S

Molar mass346.32 g·mol⁻¹

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ETX0462

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Identifiers

IUPAC name [(1R,7S)-7-(N-hydroxy-N'-methylcarbamimidoyl)-5-methyl-9-oxo-4,5,8,10-tetrazatricyclo[6.2.1.0^2,6]undeca-2(6),3-dien-10-yl] hydrogen sulfate
PubChem CID	135376294
ChemSpider	131615996
Chemical and physical data
Formula	C₁₀H₁₄N₆O₆S
Molar mass	346.32 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN=C([C@@H]1C2=C(C=NN2C)[C@@H]3CN1C(=O)N3OS(=O)(=O)O)NO
InChI InChI=1S/C10H14N6O6S/c1-11-9(13-18)8-7-5(3-12-14(7)2)6-4-15(8)10(17)16(6)22-23(19,20)21/h3,6,8,18H,4H2,1-2H3,(H,11,13)(H,19,20,21)/t6-,8-/m0/s1 Key:HXTQIYBHDSBEJG-XPUUQOCRSA-N