From 2004 to 2006, Dyangani Ose was a curator at the Centro Atlántico de Arte Moderno. In 2006, she curated the Olvida Quien Soy/ Erase Me From Who I Am exhibition, which featured works from Nicholas Hlobo, Zanele Muholi, Moshekwa Langa, and others. The exhibition focused on issues of representation.[3] She also curated projects by Alfredo Jaar, Lara Almárcegui, and Ábalos & Herreros.[1]
From 2006 to 2008, Dyangani Ose was a curator at the Centro Andaluz de Arte Contemporáneo. From 2007 to 2008, she curated the interdisciplinary project Attempt to Exhaust an African Place.[1]
From 2009 to 2010, Dyangani Ose curated Arte Invisible. In 2010, she also curated Carrie Mae Weems: Social Studies, as well as being guest curator of triennial SUD-Salon Urbain de Douala.[1]
In 2011, Dyangani Ose joined the Tate, where she worked closely with the African Acquisitions Committee and developed the museum's holdings relating to the African Diaspora.[1] This position was supported by the Guaranty Trust Bank of Nigeria.[3]
From 2012 to 2014, Dyangani Ose was responsible for the Across the Board project, which was an interdisciplinary project in London, Accra, Douala, and Lagos. She also co-curated the 2013 exhibit, Ibrahim al-Salahi: A Visionary Modernist. During 2013, she was also the Artistic Director for the third edition of Rencontres Picha. Guaranty Trust Bank.[1]
On 28 June 2014, Dyangani Ose was named curator of the eighth edition of Göteborg International Biennial for Contemporary Art (GIBCA).[1]
In 2016, Dyangani Ose was a member of the jury that selected Stan Douglas as a recipient of the Hasselblad Foundation International Award in Photography.[6]
On 10 February 2017, Dyangani Ose was named Senior Curator at Creative Time.[7]
Sponsored by Miu Miu, Dyangani Ose worked with artist Goshka Macuga on conceiving Tales & Tellers, a five-day event re-enacting the fashion brand's series of short films, as part of Art Basel Paris's public program at Palais d'Iéna in 2024.[8][9]
From 2018 to 2021, Dyangani Ose has been director and chief curator at The Showroom gallery, London.[4][10]
In 2018, Dyangani Ose was part of the selection committee that nominated Ruangrupa as artistic director of Documenta fifteen.[11] She later served on the juries that awarded the Turner Prize to Lawrence Abu Hamdan, Helen Cammock, Oscar Murillo and Tai Shani in 2019,[12] as well as the Lise Wilhelmsen Art Award to Otobong Nkanga in 2019[13] and to Guadalupe Maravilla in 2021.[14]
Dyangani Ose took over as director of MACBA in 2021.[2]