Emily Upjohn began her racing career in a novice race over nine and a half furlongs on the synthetic Tapeta track at Wolverhampton Racecourse on 23 November when she was ridden by Robert Havlin and started at odds of 12/1 against eleven opponents. She started slowly but made steady progress in the last quarter mile, took the lead in the final strides and won by a neck from Secret Image.[8]
In 2022 Emily Upjohn was ridden in all of her races by Frankie Dettori. On her seasonal debut she started 5/4 favourite for a novice race over ten furlongs on good ground at Sandown Park on 22 April. She tracked the front-running Follow That Star before taking the lead two furlongs out and drew away to win by nine and a half lengths in "impressive" style.[9] For her next start the filly was stepped up to Group 3 level for the Musidora Stakes (a trial race for the Epsom Oaks) over ten and a half furlongs at York Racecourse on 11 May. Starting the 4/7 favourite against four opponents she raced just behind the leaders before going to the front entering the last quarter mile and steadily increased her advantage to win "readily" by five and a half lengths from Life of Dreams.[10] Dettori commented "She passed a good test... She's exuberant, but also in control, which is a good combination to have. She's a big unit, she's lovely. She's got speed, she stays... for a girl that's only run three times, she hasn't stopped surprising me."[11]
On 3 June Emily Upjohn started the 6/4 favourite for 244th running of the Oaks Stakes over one and a half miles at Epsom Racecourse. She lost many lengths at the start when she stumbled exiting the stalls but recovered and appeared to be going well as she moved into contention approaching the last quarter mile. She made a sustained challenge to the leader Tuesday in the closing stages but narrowly failed to overhaul her Irish-trained rival and was beaten a short head into second place.[12] After the race Dettori said "The race was gone [at the start], I was way too far back. Bless her, she took me there in great style but the damage was done. She was a very unlucky loser."[13] The filly was then matched against male opposition and older horses in the King George VI and Queen Elizabeth Stakes over the same distance at Ascot Racecourse in July. She went off the 3/1 third choice in the betting but never looked likely to win and faded badly in the closing stages to come home last of the six runners behind Pyledriver, beaten more than twenty lengths by the winner.[14]
After a break of more than two and a half months Emily Upjohn returned to Ascot's mile and a half course for the Group 1 British Champions Fillies & Mares Stakes on good to soft ground in October. She was made the 3/1 favourite ahead of Sea La Rosa (winner of the Prix de Royallieu) and Eternal Pearl (Prix Minerve) in a fourteen-runner field which also included Verry Elleegant, Eshaada and Sweet Lady (Prix Vermeille). Emily Upjohn settled in mid-division as Rosscarberry set the pace before making progress on the outside entering the straight. She took the lead approaching the final furlong and went clear of her rivals to win by three lengths from the 50/1 outsider Thunder Kiss.[15] After the race John Gosden said "I have owners who’ve let me be patient, they’ve let me give her all the time she needed [after the King George]... I had everything right in her work and Frankie wanted to ride her, but I didn’t know about the ground. She’s a big girl but she hasn’t strengthened into her frame, she’s still quite light, so it was if she handled it. Mind you, she was so wide she was probably on fresh ground. She stays in training."[16]
In the early part of 2023 Emily Upjohn was aimed at the Dubai Sheema Classic at Meydan Racecourse in March but missed the race after failing to impress her trainer in exercise gallops. Gosden commented "She has yet to come to her peak condition and we'll wait for early summer targets here. She simply needs more time in the spring to come to herself."[17] The filly eventually began her second campaign in the Coronation Cup over one and a half miles on good to firm ground at Epsom on 2 June, With Dettori in the saddle she went off the 11/4 second favourite behind Westover in a five-runner field which also included Hurricane Lane, Point Lonsdale (Huxley Stakes) and Tunnes (Grosser Preis von Bayern). She settled at the rear of the field as Point Lonsdale set a steady pace, then moved up to take the lead in the straight. She opened up a clear advantage over her male opponents and stayed on well to win by one and three quarter lengths from Westover, with a gap of seven and a half lengths back to the others.[18] John Gosden said "She did it beautifully... She probably hit the front too soon and she’s having a really good blow so she should come on for that. She ended up in front because of the way she quickened, she’s a hugely talented filly."[19]