In May 2019, Manzelmann represented Mackay in the Northern Region Women's Championship[3] and was named in the North Queensland Women's Emerging Marlins squad.[4] In June 2019, she represented the Queensland women's under-18s team.[5] In 2020, she played for the Mackay Magpies in the Mackay women's competition,[6] before joining the North Queensland Gold Stars in the BHP Premiership.[7] In September 2021, she was named the North Queensland Gold Stars Player of the Year.[8] In December 2021, she signed with the Newcastle Knights to be a part of their inaugural NRLW squad.[9]
In round 1 of the delayed 2021 NRL Women's season, Manzelmann made her NRLW debut for the Knights against the Parramatta Eels.[10]
On 2 October, Manzelmann played in the Knights' 2022 NRLW Grand Final win over the Parramatta Eels.[11]
On 4 April, Manzelmann signed with the North Queensland Cowboys, becoming the club's inaugural signing.[12]
In June, she played both games for Queensland in their 2023 State of Origin series win over New South Wales.[13][14]
In Round 1 of the 2023 NRL Women's season, she made her debut for the Cowboys, starting at hooker and scoring the club's first try in a 16–6 loss to the Gold Coast Titans.[15]
On 28 October, she became the first Cowboy to represent Australia, coming off the bench in their 12–6 loss to New Zealand at AAMI Park.[16]
Manzelmann came off the bench for Queensland in all three games in their 2024 Women's State of Origin series win.[17]
In Round 1 of the 2024 NRL Women's season, she came off the bench in the Cowboys' 14–0 loss to the Cronulla Sharks.[18]
On 1 July, Manzelmann was named co-captain of the Cowboys alongside Kirra Dibb, replacing Tallisha Harden.[19]