After working at the British Embassy in Washington, D.C., Wade-Smith then spent six years as the United Kingdom's Trade Commissioner for Africa before being appointed Consul-General in New York and Trade Commissioner for North America in 2021.[2] In 2022 she was made honorary president of the Saint George's Society of New York.[4]
In 2024 Wade-Smith joined the De Beersdiamond company as senior vice-president for government affairs.[1][5]