Endonuclease V
Protein family
From Wikipedia, the free encyclopedia
Endonuclease V (endoV) is a highly conserved endonuclease enzyme family. The primary function of endoV differs significantly in prokaryotes and eukaryotes, as suggested by studies on the E. coli and human orthologs.
| Endonuclease V | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of Thermotoga maritima endoV (blue) in complex with DNA (green and orange). The deamidated base is shown in yellow.[1] | |||||||
| Identifiers | |||||||
| Symbol | ENDOV | ||||||
| Pfam | PF04493 | ||||||
| InterPro | IPR007581 | ||||||
| |||||||
In prokaryotes endoV is primarily a deoxyribonuclease involved in DNA repair of deoxyinosine introduced into the genome by deamidation of adenine bases (EC 3.1.21.7).[2] However, it has broad substrate specificity and can also act on other types of DNA lesions[2] as well as on inosine-containing RNA.[3]
In eukaryotes endoV is primarily a ribonuclease and cleaves single-stranded RNA at the 3' position relative to an inosine base, which may be present due to RNA editing by deaminase enzymes (EC 3.1.26.-).[4] The human endoV localizes to the cytoplasm and nucleoli, suggesting a possible role in processes involving ribosomal RNA.[3] The human gene symbol is ENDOV.
