Ependymin
Glycoprotein
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Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene.
| Ependymin Related 1 | |||||||
|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||
| Symbol | EPDR1 | ||||||
| Alt. symbols | EPDR, MERP1, UCC1 | ||||||
| Alt. names | Mammalian Ependymin-Related Protein 1, Upregulated In Colorectal Cancer Gene 1 Protein | ||||||
| NCBI gene | 54749 | ||||||
| HGNC | 17572 | ||||||
| OMIM | 619734 | ||||||
| RefSeq | NM_017549.5 | ||||||
| UniProt | Q9UM22 | ||||||
| Other data | |||||||
| Locus | Chr. 7 p14.1 | ||||||
| Wikidata | Q18041226 | ||||||
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Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration.[1] This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes.[2] Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity,[3] as well as behavioral performance in response to environment stress in fishes.[4] For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion and migration processes in the central nervous system of teleost fishes.[5] The presence of ependymin-related proteins can be found in both vertebrates and invertebrates.[6] They have variety of functional roles in non-neural sites of organisms.[6] For example, an ependymin-related gene that is upregulated in colon cancer known as UCC1 was found in human colorectal tumor cells.[7]