Ephrin A1

Ephrin A1 is a protein that in humans is encoded by the EFNA1 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesEFNA1, B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4, Ephrin A1, GMAN

External IDsOMIM: 191164; MGI: 103236; HomoloGene: 3262; GeneCards: EFNA1; OMA:EFNA1 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts EFNA1, Available structures ...

EFNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HEI, 3MBW, 3CZU
Identifiers
Aliases	EFNA1, B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4, Ephrin A1, GMAN
External IDs	OMIM: 191164; MGI: 103236; HomoloGene: 3262; GeneCards: EFNA1; OMA:EFNA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,127,876 bp[1] End 155,134,899 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.04 cM Start 89,179,040 bp[2] End 89,188,449 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right lung skin of abdomen skin of leg upper lobe of left lung left lobe of thyroid gland right lobe of thyroid gland minor salivary glands parotid gland rectum Top expressed in lip left lung lobe right lung lobe lumbar spinal ganglion right kidney colon duodenum corneal stroma jejunum proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling receptor binding ephrin receptor binding Cellular component membrane plasma membrane integral component of plasma membrane anchored component of membrane extracellular exosome intracellular anatomical structure extracellular region anchored component of plasma membrane Biological process regulation of cell adhesion mediated by integrin ephrin receptor signaling pathway aortic valve morphogenesis cell-cell signaling negative regulation of transcription by RNA polymerase II regulation of angiogenesis mitral valve morphogenesis endocardial cushion to mesenchymal transition involved in heart valve formation regulation of blood vessel endothelial cell migration regulation of axonogenesis neuron differentiation notochord positive regulation of peptidyl-tyrosine phosphorylation substrate adhesion-dependent cell spreading cell migration negative regulation of epithelial to mesenchymal transition negative regulation of dendritic spine morphogenesis regulation of peptidyl-tyrosine phosphorylation negative regulation of thymocyte apoptotic process MAPK cascade angiogenesis axon guidance positive regulation of protein phosphorylation negative regulation of MAPK cascade positive regulation of MAPK cascade protein stabilization positive regulation of protein tyrosine kinase activity positive regulation of amyloid-beta formation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1942 13636 Ensembl ENSG00000169242 ENSMUSG00000027954 UniProt P20827 P52793 RefSeq (mRNA) NM_004428 NM_182685 NM_001162425 NM_010107 RefSeq (protein) NP_004419 NP_872626 NP_001155897 NP_034237 Location (UCSC) Chr 1: 155.13 – 155.13 Mb Chr 3: 89.18 – 89.19 Mb PubMed search [3] [4]
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This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.^[7]