+ 4 reduced
ferredoxin
Epi-isozizaene 5-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Epi-isozizaene 5-monooxygenase (EC 1.14.15.39, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating).[1] This enzyme catalyses the following overall chemical reaction:
-epi-isozizaene.svg)
(+)-epi-isozizaene
2 O2
3 H2O
albaflavenone
+ 4 oxidised
ferredoxin
ferredoxin
| Epi-isozizaene 5-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.15.39 | ||||||||
| CAS no. | 1207718-51-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from Streptomyces coelicolor is an oxidoreductase which uses molecular oxygen to insert a hydroxy group into (+)-epi-isozizaene and then further oxidises that intermediate to the ketone product. It requires ferredoxin to transfer electrons to the cytochrome P450 active site.[2]
