Esprolol

Esprolol, also known as (S)-ACC-9369, is a beta blocker which was under development for the treatment of angina pectoris, anxiety disorders, and migraine.^[1][3][2] It is taken sublingually and has a rapid onset of action, short time to peak, and short duration.^[1][2] The drug is a prodrug of amoxolol, which is formed from esprolol via esterase enzymes.^[2] It is a selective β₁-adrenergic receptor antagonist.^[2][4] Esprolol was under development by Selectus Pharmaceuticals.^[1][3] It reached phase 2 clinical trials for all indications prior to the discontinuation of its development in 2001.^[1][3]

Other names(S)-ACC-9369; (S)-ACC9369

Routes of
administrationSublingual^[1][2]

Drug classBeta blocker; β₁-Adrenergic receptor antagonist

ATC code

• None

Quick facts Clinical data, Other names ...

Esprolol

Clinical data
Other names	(S)-ACC-9369; (S)-ACC9369
Routes of administration	Sublingual[1][2]
Drug class	Beta blocker; β1-Adrenergic receptor antagonist
ATC code	None
Pharmacokinetic data
Metabolism	Esterases[2]
Metabolites	Amoxolol[2]
Onset of action	"Rapid"[1][2]
Duration of action	"Short"[2]
Identifiers
IUPAC name ethyl 3-[2-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate
CAS Number	396654-09-4 112805-65-9 (hydrochloride)
PubChem CID	9950099
ChemSpider	8125710
UNII	50PY5PGT61
Chemical and physical data
Formula	C17H27NO4
Molar mass	309.406 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(=O)CCC1=CC=CC=C1OC[C@H](CNC(C)C)O
InChI InChI=1S/C17H27NO4/c1-4-21-17(20)10-9-14-7-5-6-8-16(14)22-12-15(19)11-18-13(2)3/h5-8,13,15,18-19H,4,9-12H2,1-3H3/t15-/m0/s1 Key:DMLSVZSUDBKLED-HNNXBMFYSA-N

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