Acebo studied physical activity and sport sciences at the University of Castilla–La Mancha. Her first opportunity came as host of the children's program Kosmi Club.[2] After this, she became a reporter and presenter on youth channel Non Stop People, on the Movistar+ platform.[3]
She continued to work as an actress and made her debut on national television with Ángel o Demonio (Telecinco). She also made the leap to cinema with a film by Ricardo Dávila, Los Encantados (The Enchanted Ones), which was released online in 2016.[4] Additionally, she has participated in the short film Baraka, directed by Néstor Ruiz Medina, the only Spanish-language short film selected for the Tribeca Film Festival 2016.[5]
On May 2, 2017 Money Heist premiered, in which she played Mónica Gaztambide (Stockholm), who later became one of the main characters.[6]
In 2018 she participated in the feature film Growing Up, directed by Clara Martínez-Lázaro. She starred as Diana in the 2019 miniseries Antes de perder alongside Mariam Hernández, which was released on Playz.[7] In 2020 she filmed the Spanish horror film The Chalk Line, directed by Ignacio Tatay.[8]