Nakajjigo was born in Munyonyo to Mr. and Mrs. Katergga.[1] She is the first of five children.[1] At the age of 14, Nakajjigo volunteered as a peer educator at the Kiruddu Health Centre.[1] The same year, she established the Women Health Team, a non-governmental organization aimed at educating and supporting women in Kalangala.[2] After the Kiruddu Health Centre closed for renovations, her mother gave her land in Munyonyo to build the Princess Diana Health Centre.[1] She worked to help decrease the number of teenage pregnancies.[1] For her efforts, at the age of 17, the World Health Organization named her Uganda's ambassador of hope for women and girls.[1]
Nakajjigo was a presenter on Bukedde TV. She established the reality show titled "Saving Innocence Project" to help young girls who have dropped out of school.[1] The show won a Geneva Award.[1] Nakajjigo started the "Lift: Living in the Face of Trauma" reality show.[3] She won the 2015 and 2016 World Savers awards which provided Nakajjigo with a scholarship from the Kabaka of Buganda to attend Muteesa I Royal University.[1] In 2018, she was completing a bachelor's degree in social work and social administration.[1] She was a 2018 recipient of a Mandela Washington Fellowship.[3] In June 2018, she launched the Global Girls Movement in Brussels.[4][5]
On 13 June 2019, Nakajjigo met Ludovic Michaud in Aurora, Colorado, through Tinder.[6][7] They married in a courthouse ceremony in March 2020.[6] On 13 June 2020, Nakajjigo was decapitated by a metal gate while visiting Arches National Park with her husband.[6] In January 2023, her family was awarded US$10,500,000 (equivalent to $10,836,009 in 2024) in damages by the federal government of the United States.[8]
