Estradiol valerate/cyproterone acetate
Combination drug
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Estradiol valerate/cyproterone acetate (EV/CPA), sold under the brand names Climen and Femilar among others, is a combination product of estradiol valerate (EV), an estrogen, and cyproterone acetate (CPA), a progestogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy.[1] It is taken by mouth.[1] Climen, which is used in menopausal hormone therapy, is a sequential preparation that contains 2 mg estradiol valerate and 1 mg CPA.[2][3][4] It was the first product for use in menopausal hormone therapy containing CPA to be marketed[3] and is available in more than 40 countries.[2] Femilar, which is an estradiol-containing birth control pill, contains 1 to 2 mg estradiol valerate and 1 to 2 mg CPA, and has been approved for use in Finland since 1993.[5]
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 | |
| Combination of | |
|---|---|
| Estradiol valerate | Estrogen |
| Cyproterone acetate | Progestogen |
| Clinical data | |
| Trade names | Climen, Femilar |
| Other names | EV/CPA |
| Routes of administration | By mouth |
| Drug class | Estrogen; Progestogen |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
CPA alone has been found to suppress ovulation in 3 of 5 women at a dose of 0.5 mg/day and in 5 of 5 women at a dose of 1 mg/day.[6][7][8][9][10][11] Ovulation inhibition with Femilar occurred in 94.4% of 108 women during the third treatment cycle in one study and in almost 100% of 26 women over 12 treatment cycles in another study (except for one woman who ovulated during her first treatment cycle).[5][12][1]
