After his junior season, Sisk was selected by the St. Louis Cardinals in the 16th round, with the 483rd overall pick, of the 2018 Major League Baseball draft.[2]
Sisk signed with the Cardinals and made his professional debut with the Johnson City Cardinals, posting a 1.76 ERA over 30+2⁄3 innings.[3] He spent the 2019 season with the Peoria Chiefs where he went 3–6 with a 3.25 ERA over 61 innings pitched in relief. Sisk did not play a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.[4] He opened the 2021 season with Peoria and was promoted to the Double-A Springfield Cardinals during the season.
Minnesota Twins
On July 30, 2021, the Cardinals traded Sisk and John Gant to the Minnesota Twins in exchange for J.A. Happ and cash.[5] He was assigned to the Double-A Wichita Wind Surge where he finished the season. Over 39 relief appearances between Peoria, Springfield and Wichita, Sisk went 3–1 with a 3.91 ERA and 69 strikeouts over 53 innings. After the season, he played in the Arizona Fall League for the Scottsdale Scorpions.[6] He opened the 2022 season with Wichita and was promoted to the St. Paul Saints in mid-June.[7] Over fifty relief appearances between the two teams, he went 5–1 with a 1.57 ERA and 76 strikeouts over 63 innings.[8]
Sisk made 58 appearances for Triple–A Omaha in 2024, compiling a 6–2 record and 1.57 ERA with 81 strikeouts and 15 saves across 57+1⁄3 innings pitched. On November 1, 2024, the Royals added Sisk to their 40-man roster to prevent him from reaching minor league free agency.[11]
Sisk was optioned to Triple-A Omaha to begin the 2025 season.[12] On April 13, 2025, Sisk was promoted to the major leagues for the first time.[13] He made his MLB debut on April 15 at Yankee Stadium, pitching one scoreless inning in which he gave up one walk, one hit, and acquired all three outs via strikeout. Sisk made five appearances for the Royals, recording a 1.69 ERA with 11 strikeouts across 5+1⁄3 innings pitched.
Pittsburgh Pirates
On July 31, 2025, Sisk and Callan Moss were traded to the Pittsburgh Pirates in exchange for pitcher Bailey Falter.[14] On August 18, Sisk recorded his first career win, tossing a scoreless inning of relief against the Toronto Blue Jays.[15] Sisk made 14 appearances for Pittsburgh down the stretch, compiling a 1–1 record and 4.38 ERA with a 14/5 (2.8) strikeout-to-walk ratio across 12+1⁄3 innings pitched.[16]
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